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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

1. An immunocompromised patient develops a disseminated fungal infection. Tissue biopsy reveals small (2-4
µm) yeast cells within macrophages. The patient has a history of living in the Ohio and Mississippi River valleys. The MOST likely causative agent is:

A) Paracoccidioides brasiliensis
B) Blastomyces dermatitidis
C) Histoplasma capsulatum
D) Penicillium marneffei

2. Which of the following bacterial genera inherently possesses D-alanyl-D-lactate peptide subunits in its peptidoglycan precursors, conferring natural, high-level resistance to vancomycin?

A) Leuconostoc
B) Streptococcus
C) Enterococcus (e.g., E. gallinarum, E. casseliflavus carrying vanC)
D) Staphylococcus

3. A patient with HIV infection and a low CD4+ T-cell count presents with fever, weight loss, and cough. Chest X-ray shows diffuse interstitial infiltrates. Sputum induction reveals oval yeast cells with narrow-based budding. The MOST likely diagnosis is:

A) Pneumocystis pneumonia
B) Histoplasmosis
C) Tuberculosis
D) Cryptococcosis

4. A clinical microbiology laboratory is implementing a new MALDI-TOF mass spectrometry system for bacterial identification. For accurate identification, the system relies on comparing the protein profile of an unknown isolate to:

A) A database of bacterial cell wall lipid compositions.
B) A database of protein mass spectra from well-characterized organisms.
C) A database of known bacterial ribosomal RNA sequences.
D) A database of antibiotic resistance genes.

5. A microbiology laboratory is performing Gram staining on a bacterial smear. If the safranin counterstain is omitted, Gram-negative bacteria will appear:

A) Brown
B) Purple
C) Blue
D) Colorless

Solutions: